QUANTITATIVE PREDICTION OF HUMAN PHARMACOKINETICS AND PHARMACODYNAMICS OF CKD519, A POTENT INHIBITOR OF CHOLESTERYL ESTER TRANSFER PROTEIN (CETP)

Quantitative Prediction of Human Pharmacokinetics and Pharmacodynamics of CKD519, a Potent Inhibitor of Cholesteryl Ester Transfer Protein (CETP)

CKD519, a selective inhibitor of cholesteryl ester transfer protein(CETP), is undergoing development as an oral agent for the treatment of primary hypercholesterolemia and mixed hyperlipidemia.The aim of this study was to predict the appropriate efficacious dose of CKD519 for humans in terms of the inhibition of CETP activity by developing a CKD519

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YOLOv8-MPEB small target detection algorithm based on UAV images

Target detection in Unmanned Aerial Vehicle (UAV) aerial images has gained significance within UAV application scenarios.However, UAV aerial images present challenges, including large-scale changes, small target sizes, complex scenes, and variable external factors, resulting in missed or false detections.This study proposes an algorithm for small t

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